Description: This creative nonfiction dissertation is a memoir of the author's search for the somewhat mysterious hidden past of her father, the lexicographer Charles J. Lovell, who died in 1960, when the author was nine. Her father's early death left the author with many unanswered questions about his past and his family and so she undertakes a search to answer, if possible, some of those questions. Her search takes her to Portland, Maine; New Bedford, Massachusetts; and Pasadena, California, where she tries to discover the facts and uncover the forces that shaped her father's life. Along the way, she realizes how profoundly his death affected and shaped her own life, contributing to the theme of loss that pervades the memoir. In addition, she begins to realize how much her mother, Dixie Hefley Lovell, whose significance she previously overlooked, shaped her life. Ultimately, she comes to understand and accept that some of her questions are unanswerable.

Description: This dissertation argues that the strong relationship that historians see between the South and West in the early 19th century, which allowed them to form what scholars have termed the Old South, had its origins in the twenty-year period after the American Revolution when a group of far-sighted southerners worked to form a political bond between the two regions. They did so by tirelessly defending the West and westerners against political and economic attacks, often from northerners but sometimes from people within their own region. Within the ongoing debate over the emergence of a southern consciousness, historians have overlooked one important factor in its development-the West. Although it would be incorrect to argue that southern consciousness began in the 1780s or 1790s, it would not be remiss to argue that southerners began to look at the trans-Appalachian West during this period as something more than just virgin territory. A few southerners, particularly James Madison, saw the South's political future entwined with the West's advancement and worked to ensure that a strong political relationship developed between the two regions. For people like Madison, this political merger of the two sections is what they meant when they talked about a "southern and ...

Description: This study examined a new model of paclitaxel-induced neuropathic pain and the effects of systemic paclitaxel on the gap junction protein subunit Cx43 and potassium inwardly-rectifying channel Kir4.1 within the dorsal root ganglia. In the new neuropathic pain model, subplantar injections of paclitaxel resulted in decreased conduction velocities of A-beta fiber compound action potentials in the sciatic (5.9%) and tibial nerves (6.8%) as well as in M (10.6%) and H (10.2%) waves. By using repeated recordings it was found that following paclitaxel injection, conduction velocities in the contralateral plantar nerve increased (9.2%). Systemic injections of paclitaxel resulted in reduced Kir4.1 immunolabeling in the dorsal root ganglia compared to vehicle injections. This reduction was observed in total labeling (32.4%) as well as in areas of intense labeling (28.7%). Reductions in overall Cx43 immunolabeling (25%) and area (25%) following systemic paclitaxel injections were not statistically significant. The results of these studies suggest that subplantar injections of paclitaxel can result in reduced peripheral nerve conduction velocities. The results also show that a unilateral neuropathy can result in contralateral changes in conduction velocities. The effects of paclitaxel on reducing Kir4.1 levels suggest that neuropathic pain caused by paclitaxel may share mechanisms in common with ...

Description: Cosmology, as an all-encompassing theoretical construction of universal reality, serves as one of the best indicators for a variety of philosophical, scientific, and cultural values. Within any cosmological system, the question of extraterrestrial life is an important element. Mere existence or nonexistence, however, only exposes a small portion of the ideological significance behind the contemplation of life outside of earth. The manners by which both believers and disbelievers justify their opinions and the ways they characterize other worlds and their inhabitants show much more about the particular ideas behind such decisions and the general climate of thought surrounding those who consider the topic. By exploring both physical and abstract structures of the universe, and specifically concepts on the plurality of worlds and extraterrestrial life, Western European thought in the seventeenth and eighteenth centuries reveals not an era of pure advancement and modernization, but as a time of both tradition and change.

Description: This study examines upward economic mobility into the planter class in Texas during the antebellum statehood period, 1846-1860. Using quantitative methods to analyze data from census and tax records, this study addresses several questions regarding the property owning experience of Texas planters. Did any of the 1860 planters, men or women, rise to that status from another class? If so, how many rose from small slaveholder or small planter origins, and how many advanced from plain folk origins? In what ways did the amount and nature of wealth of these individuals change in the period studied? In what ways do these findings provide insights into the debate over planter dominance versus ‘plain folk’ inclusive herrenvolk democracy and the relationship between the planters and the other classes? Did the experiences of female planters differ from that of male planters? Did female planter experiences in Texas differ from female planters in other parts of the Old South? The results of these questions demonstrate that economic class mobility into the richest class was significant but limited and that women’s experiences were closely tied to those of male kin.