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Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol

Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol

Date: August 2002
Creator: Xia,Yun
Description: Embryonic murine neuronal networks cultured on microelectrode arrays were used to quantify acute electrophysiological effects of fluoxetine and ethanol. Spontaneously active frontal cortex cultures showed highly repeatable, dose-dependent sensitivities to both compounds. Cultures began to respond to fluoxetine at 3 µM and were shut off at 10-16 µM. EC50s mean ± S.D. for spike and burst rates were 4.1 ± 1.5 µM and 4.5 ± 1.1 µM (n=14). The fluoxetine inhibition was reversible and without effect on action potential wave shapes. Ethanol showed initial inhibition at 20 mM, with spike and burst rate EC50s at 52.0 ± 17.4 mM and 56.0 ± 17.0 mM (n=15). Ethanol concentrations above 100 -140 mM led to cessation of activity. Although ethanol did not change the shape and amplitude of action potentials, unit specific effects were found. The combined application of ethanol and fluoxetine was additive. Ethanol did not potentiate the effect of fluoxetine.
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Neuropsychologic correlates of a normal EEG variant: The mu rhythm.

Neuropsychologic correlates of a normal EEG variant: The mu rhythm.

Date: August 2008
Creator: Simms, Lori A.
Description: Although the mu rhythm is traditionally defined as a normal EEG variant, recent evidence suggests that mu may have functional significance in a variety of disorders such as autism, Parkinson's disease, and multiple sclerosis. While an increasing number of articles have focused on the blocking mechanism of mu in relation to various cognitive processes and disorders, few have examined the significance of a prominent mu rhythm in the background EEG. A few studies have examined the relationship between the mu rhythm and psychological disturbance, such as attentional and affective disorders. Increasing evidence suggests that EEG and qEEG variables may be useful in classifying psychiatric disorders, presenting a neurophysiological alternative to traditional symptom-based diagnosis and classification. Thus, the intention of the present study was to examine the relationship between neuropsychological variables, gathered from multiple assessment sources, and the presence of a prominent mu rhythm in the EEG. Results did not show a statistically significant difference between individuals with and without a prominent mu rhythm on the Test of Variables of Attention (TOVA); although individuals in the mu group showed a pattern of increased impulsivity and performance decrement over time. For adults, no significant differences were observed between groups on psychological variables ...
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Neuropsychological Functioning in Active Duty Soldiers with Physical and/or Psychological Trauma

Neuropsychological Functioning in Active Duty Soldiers with Physical and/or Psychological Trauma

Date: December 2010
Creator: Klein, Robert S.
Description: This quasi-experimental study investigates neuropsychological functioning differences between 63 active duty soldiers who were placed into three groups (MTBI, PTSD, control) to provide better information for differentiating PTSD and MTBI. The ANAM and MicroCog were utilized to measure psychomotor speed, memory, and attention. Participants with PTSD performed worse on most measures of psychomotor speed and attention, and endorsed more symptoms of depression and anxiety when compared to MTBI and control participants. Further, attention appears to be the best cognitive domain for differentiating PTSD from MTBI, whereas memory variables did not differentiate these groups. Clinical and research implications of these findings are discussed.
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Neuropsychological Functioning in Non-Schizophrenic First-Degree Relatives of Schizophrenics

Neuropsychological Functioning in Non-Schizophrenic First-Degree Relatives of Schizophrenics

Date: August 1998
Creator: Suire, David M. (David Mark)
Description: Research has consistently shown schizophrenics to perform significantly poorer than normal controls on commonly used measures of neuropsychological functioning. Research on the neuropsychological functioning of first-degree relatives of schizophrenics who do not themselves have schizophrenia is comparatively sparse but suggests the likelihood of deficits in this group as well. A battery of standard neuropsychological tests was administered to three groups: first-degree relatives of schizophrenics who do not themselves have schizophrenia (FDR-SCZ), first-degree relatives of persons with major depression and bipolar disorder (FDR-MOOD), and normal controls (NC). The FDRSCZ group was not found to demonstrate significantly impaired performance relative to the other two groups on any of the hypothesized or exploratory analyses. These implications of these findings are discussed with reference to previous studies and future research.
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Neuropsychological Predictors of Incompetency to Stand Trial

Neuropsychological Predictors of Incompetency to Stand Trial

Date: December 2004
Creator: Grandjean, Nicole Rae
Description: This study investigated the effect of cognitive factors on competency to stand trial. Previous researchers have investigated how psychological variables --such as psychosis and intelligence--contribute to incompetency. Although several researchers have established that intelligence contributes to incompetency, very few have investigated the role of specific cognitive abilities within the realm of intelligence. This study investigated the performance of 55 defendants referred for competency restoration on neuropsychological measures. Specifically, competent defendants and incompetent defendants were compared on several measures assessing functioning in seven cognitive domains. Competent defendants performed significantly better than incompetent defendants on measures of verbal comprehension, social judgment, verbal memory, and executive functioning. Competent and incompetent defendants did not differ on attention, visual spatial skills, or nonverbal memory.
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Neuroticism and Religious Coping Styles as Mediators of Depressive Affect and Perceived Stress

Neuroticism and Religious Coping Styles as Mediators of Depressive Affect and Perceived Stress

Date: August 2005
Creator: Crostley, Jeremy T.
Description: Previous researchers have shown that the collaborative, self-directing, and deferring styles of religious coping result in different outcomes of depression under different levels of perceived stress. Neuroticism has also been shown to affect coping effectiveness overall or choice of coping method. However, little work has been done to investigate the association between neuroticism and the choice or effectiveness of religious coping styles in particular, or on the association of neuroticism and perceived stress. The present study addressed research questions by examining relations among neuroticism, perceived stress, objective life events, religious and non-religious coping styles, effectiveness of coping styles, and depression. Hierarchical multiple regression and correlational techniques found that religious coping styles predict depression, religious and non-religious coping correspond, and neuroticism predicts perceived stress beyond situational stressors. Neuroticism did not predict use of religious coping styles, but remaining personality factors were successful in predicting coping. Implications, limitations, and future directions are discussed.
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Neutron Density Depression Due to an Oblate Spheroidal Detector

Neutron Density Depression Due to an Oblate Spheroidal Detector

Date: January 1954
Creator: Trammell, Margaret Ruth
Description: In this paper, two projects have been undertaken. First, Workman's calculations have been checked to a higher degree of approximation to determine the accuracy of his method. Second, a new set of boundary conditions has been developed for obtaining solutions of the neutron diffusion equation which do not depend on the solution of the equation inside the detector.
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Neutron Transmutation and Hydrogenation Study of Hg₁₋xCdxTe

Neutron Transmutation and Hydrogenation Study of Hg₁₋xCdxTe

Date: December 2007
Creator: Zhao, Wei
Description: Anomalous Hall behavior of HgCdTe refers to a "double cross-over" feature of the Hall coefficient in p-type material, or a peak in the Hall mobility or Hall coefficient in n-type material. A magnetoconductivity tensor approach was utilized to identify presence of two electrons contributing to the conduction as well as transport properties of each electron in the material. The two electron model for the mobility shows that the anomalous Hall behavior results from the competition of two electrons, one in the energy gap graded region near the CdZnTe/HgCdTe interface with large band gap and the other in the bulk of the LPE film with narrow band gap. Hg0.78Cd0.22Te samples grown by LPE on CdZnTe(111B)-oriented substrates were exposed to various doses of thermal neutrons (~1.7 x 1016 - 1.25 x 1017 /cm2) and subsequently annealed at ~220oC for ~24h in Hg saturated vapor to recover damage and reduce the presence of Hg vacancies. Extensive Magnetotransport measurements were performed on these samples. SIMS profile for impurities produced by neutron irradiation was also obtained. The purpose for this study is to investigate the influence of neutron irradiation on this material as a basis for further study on HgCdTe74Se. The result shows that total ...
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Never Odd Or Even: Using Temporal Structures In Composing Music For Dance

Never Odd Or Even: Using Temporal Structures In Composing Music For Dance

Date: May 2012
Creator: Bernardo, Daniel
Description: This study engages the collaboration of dance and music, focusing primarily on experiences in the production of a large scale collaborative concert entitled Never Odd or Even. Famous historical collaborations offer archetypal collaborative models, the more unconventional of which are applied to the pieces of the concert. Issues and observations regarding cross-influence, project evolution, and application of the collaborative models are engaged to determine effective means of collaboration given different circumstances. The key focus of the study, the temporal relationship between music and dance, is explored in great detail to determine three models for relating time between music and dance. These temporal relationship models are applied to the pieces and evaluated on effectiveness and potential strengths when applied to dance.
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I Never Saw Another Butterfly: A Composition for SATB Choir and Chamber Orchestra

I Never Saw Another Butterfly: A Composition for SATB Choir and Chamber Orchestra

Date: August 1997
Creator: Schneider, Gregory Alan
Description: ...I never saw another butterfly... is a twelve movement chamber work scored for SATB choir, narrator, percussion I [vibraphone, and tomtoms (4)], percussion II [timpani (4), tam-tam, snare drum, and bass drum], guitar, violins I and II, viola, and cello and is based on the book of the same name. It contains a variety of compositional techniques, forms and genres.
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