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  Partner: UNT Libraries
 Collection: UNT Theses and Dissertations
NSAID effect on prostanoids in fishes: Prostaglandin E2 levels in bluntnose minnows (Pimephales notatus) exposed to ibuprofen.

NSAID effect on prostanoids in fishes: Prostaglandin E2 levels in bluntnose minnows (Pimephales notatus) exposed to ibuprofen.

Date: August 2009
Creator: Bhandari, Khageshor
Description: Prostanoids are oxygenated derivatives of arachidonic acid with a wide range of physiological effects in vertebrates including modulation of inflammation and innate immune responses. Nonsteroidal anti-inflammatory drugs (NSAIDs) act through inhibition of cyclooxygenase (COX) conversion of arachidonic acid to prostanoids. In order to better understand the potential of environmental NSAIDS for interruption of normal levels COX products in fishes, we developed an LC/MS/MS-based approach for tissue analysis of 7 prostanoids. Initial studies examining muscle, gut and gill demonstrated that prostaglandin E2 (PGE2) was the most abundant of the measured prostanoids in all tissues and that gill tissue had the highest and most consistent concentrations of PGE2. After short-term 48-h laboratory exposures to concentrations of 5, 25, 50 and 100 ppb ibuprofen, 50.0ppb and 100.0 ppb exposure concentrations resulted in significant reduction of gill tissue PGE2 concentration by approximately 30% and 80% respectively. The lower exposures did not result in significant reductions when compared to unexposed controls. Measured tissue concentrations of ibuprofen indicated that this NSAID had little potential for bioaccumulation (BCF 1.3) and the IC50 of ibuprofen for inhibition of PGE2 production in gill tissue was calculated to be 0.4 µM. Short-term laboratory exposure to ibuprofen did not result in ...
Contributing Partner: UNT Libraries
Nuclear Magnetic Resonance in a Crystalline Stable Free Radical--Wurster's Blue Perchlorate

Nuclear Magnetic Resonance in a Crystalline Stable Free Radical--Wurster's Blue Perchlorate

Date: August 1965
Creator: McCann, Thomas E.
Description: This thesis investigates the nuclear magnetic resonance in a crystalline stable free radical.
Contributing Partner: UNT Libraries
Nuclear Magnetic Resonance in Hydrated Crystals - Potassium Oxalate Monohydrate

Nuclear Magnetic Resonance in Hydrated Crystals - Potassium Oxalate Monohydrate

Date: May 1962
Creator: Mason, Charley Mack
Description: The problem of this study was the measurement of the proton-proton separation in the water molecule of hydration in a single crystal of potassium oxalate monohydrate.
Contributing Partner: UNT Libraries
Nuclear Magnetic Resonance Spectra of Some 1,2,4-triazoles

Nuclear Magnetic Resonance Spectra of Some 1,2,4-triazoles

Date: January 1967
Creator: Creagh, Linda Truitt
Description: In the work undertaken here, NMR has been used to ascertain the structure of some 1,2,4-triazoles. The investigation provides information concerning the structure of potentially tautomeric triazoles such as hydroxy- and aminotriazole. Connected with this aspect of triazole chemistry is the larger problem of mesohydric tautomerism. The present study also yields information for a comparison of substituent effects in triazoles, N-heteroaromatic substances and benzene.
Contributing Partner: UNT Libraries
Nuclear Reactions on the Palladium Isotopes

Nuclear Reactions on the Palladium Isotopes

Date: December 1970
Creator: White, Ronald Lee
Description: The problem of interest in this investigation was to determine the cross sections of five nuclear reactions which occur when irradiating natural palladium with neutrons which have energy values of 15.1, 15.9, and 16.3 MeV. The cross sections were measured relative to a copper monitor which was "sandwitched" in with the palladium target.
Contributing Partner: UNT Libraries
Nucleotide Inhibition of Glyoxalase II

Nucleotide Inhibition of Glyoxalase II

Date: May 1999
Creator: Gillis, Glen S
Description: The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the isomerization of a hemithioacetal, formed non-enzymatically from methylglyoxal and GSH, to the corresponding a -D-hydroxyacid thioester, s-D-lactoylglutathione (SLG). Glo-II catalyzes the irreversible breakdown of SLG to D-lactate and GSH. We have observed that ATP or GTP significantly inhibits the Glo-II activity of tissue homogenates from various sources. We have developed a rapid, one step chromatography procedure to purify Glo-II such that the purified enzyme remains "sensitive" to inhibition by ATP or GTP (Glo-II-s). Studies indicate that inhibition of Glo-II-s by nucleotides is restricted to ATP, GTP, ADP, and GDP, with ATP appearing most effective. Kinetics studies have shown that ATP acts as a partial non-competitive inhibitor of Glo-II-s activity, and further suggest that two kinetically distinguishable forms of the enzyme exist. The sensitivity of pure Glo-II-s to nucleotide inhibition is slowly lost on storage even at -80° C. This loss is accelerated at higher temperatures or in the presence of ATP. Kinetics studies on the resultant "insensitive" ...
Contributing Partner: UNT Libraries
Nucleotide Sequence of a Bovine Arginine Transfer RNA Gene

Nucleotide Sequence of a Bovine Arginine Transfer RNA Gene

Date: May 1996
Creator: Eubanks, Aleida C. (Aleida Christine)
Description: A single plaque-pure lambda clone designated λBA84 that hybridized to a ˆ32P-labeled bovine arginine tRNA was isolated from a bovine genomic library harbored in a lambda bacteriophage vector. A 2.3-kilobase segment of this clone was found to contain an arginine transfer RNAccg gene by Southern blot hybridization analysis and dideoxyribonucleotide DNA sequencing. This gene contains the characteristic RNA polymerase III split promoter sequence found in all eukaryotic tRNAs and a potential RNA polymerase III termination site, consisting of four consecutive thymine residues, in the 3'-flanking region. Several possible cis-acting promoter elements were found within the 5'-flanking region of the sequenced gene. The function of these elements, if any, is unknown.
Contributing Partner: UNT Libraries
Number Theoretic Analogies for Certain Theorems and Processes in the Theory of Equations

Number Theoretic Analogies for Certain Theorems and Processes in the Theory of Equations

Date: 1940
Creator: Witt, F. L.
Description: The aim of this paper is to exhibit analogs in Number Theory of certain well known theorems and methods of the Theory of Equations.
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A Numerical Method for the Calculation of the Inertial Loads on an Airplane

A Numerical Method for the Calculation of the Inertial Loads on an Airplane

Date: 1958
Creator: Williams, Glen R.
Description: This paper is an extension of various projects that the writer has been associated with at Chance Vought Aircraft, Incorporated.
Contributing Partner: UNT Libraries
Le Nuove Musiche: Giovanni Battista Bovicelli?

Le Nuove Musiche: Giovanni Battista Bovicelli?

Date: August 2010
Creator: Gámez Hernández, Carlos
Description: This thesis is a comparative study on the late 16th century manuals of ornamentation by Girolamo Dalla Casa, Giovanni Bassano, Riccardo Rognoni, and Giovanni Battista Bovicelli. The study demonstrates that the latest Renaissance manual should be given more credit for the innovative ornamentation style that was to come in the Early Baroque era. Bovicelli's use of sequence, dissonances, and less moving notes for more rhythmic varieties are features most often associated in the style of the Baroque. Unfortunately, the topic of ornamentation in the late Renaissance is most commonly discussed as a group of different entities writing in the same style. The research for this paper is intended to separate the manuals of the late Renaissance, focusing on the separate styles that led to the work of Giovanni Battista Bovicelli.
Contributing Partner: UNT Libraries