You limited your search to:

  Partner: UNT Libraries
 Collection: UNT Theses and Dissertations
Investigation of the Pharmacokinetics of Diazepam in Juvenile Channel Catfish (Ictalurus Punctatus)

Investigation of the Pharmacokinetics of Diazepam in Juvenile Channel Catfish (Ictalurus Punctatus)

Date: December 2013
Creator: Overturf, Carmen L.
Description: The presence of pharmaceuticals in the environment is becoming an increasing regulatory and scientific concern. Thus, the metabolic profile and bioconcentration potential of diazepam, a model benzodiazepine, were examined, as well as effects on the endocrine system in channel catfish. Through the use of specific and non-specific cytochrome P450 (CYP450) inhibitors, it was determined that CYP3A-like enzymes may play a role in the biotransformation of diazepam into temazepam; however, the isoform(s) required for the formation of other metabolites is still unknown. Overall, only around 7-8% of diazepam is biotransformed into two known metabolites. Due to the lack of inherent metabolism of diazepam in channel catfish, further analysis was conducted to determine the tissue-specific bioconcentration potential of diazepam in catfish. Various tissues were analyzed for the presence of diazepam as well as metabolites and bioconcentration factors (BCF) were calculated, which were all well below regulatory threshold values (> 2000). Additionally, modulation of the endocrine system by diazepam was examined by measuring steroid hormone concentrations and analyzing mRNA expression of selected steroidogenic enzymes and receptors. Two steroidogenic enzymes were modulated following diazepam exposure, indicating potential endocrine disrupting properties of diazepam. Together, these data suggest that diazepam exhibits low metabolic transformation rates in ...
Contributing Partner: UNT Libraries
An Investigation of the Phase Model of Psychotherapy Across Therapeutic Orientations: Are Different Approaches Actually All That Different?

An Investigation of the Phase Model of Psychotherapy Across Therapeutic Orientations: Are Different Approaches Actually All That Different?

Date: August 2013
Creator: Herbert, Gregory L.
Description: The current study investigated the process of change underlying two different evidence-based treatments that yield similar outcome effectiveness in the treatment of depression: Cognitive Therapy (CT) and Interpersonal Therapy (IPT). The phase model of psychotherapeutic change (Howard et al., 1993) change is used to provide both a theoretical and practical framework in which to assess different patterns of change across the treatment modalities. The phase model posits that recovery from distress occurs in three sequential stages: remoralization, remediation and rehabilitation. CT can be conceptualized as a treatment in which the primary focus is on the treatment of symptoms (remediation), whereas IPT can typically be conceptualized as focusing on interpersonal conflicts and functioning (rehabilitation). The study utilized the TDCRP dataset (Elkin et al., 1985). Survival analysis indicated no significant difference in terms of onset or pattern of improvement across treatment orientations. Chi square analyses indicated individuals treated with IPT spend significantly more time engaged in rehabilitation compared to their CT counterparts. Taken together, these findings represent evidence that the process of therapeutic change is similar, if not virtually identical, across therapeutic orientation. The analyses also indicate that the phases of therapy may not necessarily be mutually exclusive and sequential, but may ...
Contributing Partner: UNT Libraries
Investigation of the Possible Application of High and Low Frequency Conductance Measurements to the Analysis of Poly-Component Systems

Investigation of the Possible Application of High and Low Frequency Conductance Measurements to the Analysis of Poly-Component Systems

Date: 1956
Creator: Pinkerton, K. Allan
Description: The immediate goal of this thesis was the analysis of a three-component system whose major component was water. This analysis was to be the result of a procedure which could be readily extended to more complex systems.
Contributing Partner: UNT Libraries
Investigation of the Pressure Dependence of SO3    Formation

Investigation of the Pressure Dependence of SO3 Formation

Date: December 2003
Creator: Naidoo, Jacinth
Description: The kinetics of the pressure dependent O + SO2 + Ar reaction have been investigated using laser photolysis resonance fluorescence at temperatures of 289 K, 399 K, 581 K, 699 K, 842 K and 1040 K and at pressures from 30-665 torr. Falloff was observed for the first time in the pressure dependence. Application of Lindemann theory yielded an Arrhenius expression of k(T) = 3.3 x 10-32exp(-992/T) cm6 molecule-1 s-1 for the low pressure limit and k(T) = 8.47 x 10-14exp(-468/T) cm3 molecule-1 s-1 for the high pressure limit at temperatures between 289 and 842 K. The reaction is unusual as it possesses a positive activation energy at low temperature, yet at higher temperatures the activation energy is negative, illustrating a reaction barrier.
Contributing Partner: UNT Libraries
An Investigation of the Relationship between Girls' Reasons for Electing Homemaking and Their Vocational Preferences and Aptitudes

An Investigation of the Relationship between Girls' Reasons for Electing Homemaking and Their Vocational Preferences and Aptitudes

Date: January 1953
Creator: Francis, Edna
Description: A review of preceding studies reveals a number of factors which influence junior- and senior-high-school girls to elect homemaking. The present study proposes to discover additional factors. It, furthermore, proposes to determine whether any relationships exist between the expressed interests of students who elect homemaking and their vocational preferences and general aptitudes.
Contributing Partner: UNT Libraries
An Investigation of the Relationship between HIV and Prison Facilities in Texas: The Geographic Variation and Vulnerable Neighborhood Characteristics

An Investigation of the Relationship between HIV and Prison Facilities in Texas: The Geographic Variation and Vulnerable Neighborhood Characteristics

Date: August 2011
Creator: Kutch, Libbey
Description: Previous research suggests that prisons may be fueling the spread of HIV infection in the general population. In 2005, the HIV rate was more than 2.5 times higher in US prison populations. Environmental factors in prisons such as illicit drug use and unprotected sexual activities can be conducive for HIV transmission. Because the vast majority of prison inmates are incarcerated for less than three years, transmission of HIV between prison inmates and members of the general population may occur at a high rate. The environment in which an individual lives and the entities that comprise it affect the health of that person. Thus the location of prisons within communities, as well as socio-demographic characteristics may influence the geography of HIV infection. HIV surveillance data, obtained from the Texas Department of State Health Services, were used to investigate the relationship between the location of prison units in Texas and HIV infection rates in the surrounding zip codes. The results suggest that HIV prevalence rates are higher among geographic areas in close proximity to a prison unit. With continued behavioral risks and low treatment adherence rates among individuals infected with HIV, there is a possibility of increased HIV prevalence. Vulnerable places, locations ...
Contributing Partner: UNT Libraries
An Investigation of the Relationship between Intelligence, Self-Concept and Social Competency among the Mentally Retarded

An Investigation of the Relationship between Intelligence, Self-Concept and Social Competency among the Mentally Retarded

Date: December 1972
Creator: Terrill, Nolan Allan
Description: The purpose of this study is to add to the body of knowledge concerning intelligence, self-concept, and social competency as related to the habilitation of retardates by investigating the following problem: what is the relationship between intelligence, self-concept, and social competency among the mentally retarded?
Contributing Partner: UNT Libraries
An Investigation of the Relationship of Selected Variables to Sight-singing Ability

An Investigation of the Relationship of Selected Variables to Sight-singing Ability

Date: August 1968
Creator: Read, John William
Description: The problem is a study of the relationship of selected musical and extra-musical variables to sight-singing ability.
Contributing Partner: UNT Libraries
An Investigation of the Relationship of Self-Concept and Selected Personal Characteristics of Student Teachers to Success in Student Teaching

An Investigation of the Relationship of Self-Concept and Selected Personal Characteristics of Student Teachers to Success in Student Teaching

Date: August 1970
Creator: Passmore, Wynoka Sue, 1941-
Description: The problem of this study was to determine the relationships that exist between elementary student teachers' personality factors and success in student teaching.
Contributing Partner: UNT Libraries
An investigation of the relationships between job characteristics, satisfaction, and team commitment as influenced by organization-based self-esteem within a team-based environment

An investigation of the relationships between job characteristics, satisfaction, and team commitment as influenced by organization-based self-esteem within a team-based environment

Access: Use of this item is restricted to the UNT Community.
Date: August 2000
Creator: Abbott, John B.
Description: Team-based management is a popular contemporary method of redesigning jobs in order to more effectively utilize the human potential of employees. The use of such management techniques should result in increased satisfaction and team commitment; however, many research studies have failed to demonstrate increases in affective outcomes on the part of the employee. The research question examined in this study is, "What specific job dimensions and situational factors result in higher levels of satisfaction and team commitment?" The Job Characteristics Model (Hackman & Oldham, 1975) provided a basis for this study. The model was designed for individual contributors and has not been extensively used in team research. As expected it was found that within a team-based environment higher levels of the five core job dimensions of skill variety, task identity, task significance, autonomy, and job feedback were associated with increased satisfaction and team commitment. Organization-based self-esteem was found to mediate the relationship between the five core job dimensions and the affective outcome variables. Contrary to expectations, however, it was found that consultative team members experienced higher levels of satisfaction and commitment than substantive team members. In addition, consultative team members reported higher levels of two core job dimensions, skill variety ...
Contributing Partner: UNT Libraries