Date: May 2012
Creator: Curtis, John Harper
Description: Human immunodeficiency virus (HIV) and substance abuse (drug and/or alcohol) independently impair the immune system; importantly, the combination of HIV infection and substance abuse might produce more than an additive effect on this system. Tumor necrosis factor-alpha (TNF-?) and Interferon gamma (IFN?) are pro-inflammatory cytokines involved in differentiation of Th0 cells into Th1 cells. Interleukin 4 (IL-4) and Interleukin 10 (IL-10) are anti-inflammatory cytokine involved in differentiation of Th0 cells to Th2 cells. Unbalanced Th1 and Th2 cells can lead to immune suppression. Thus, changes in these cytokines could have important implications for people infected with HIV (HIV+). Resistance training can counteract muscle wasting, improve strength, and improve muscle mass. The purpose of this study was to examine the effect of resistance training on resting concentrations of circulating TNF-?, IFN-?, IL-4, and IL-10. Sixteen men (42 ± 11 years, 180.4 ± 9.1 cm, 89.2 ± 20.7 kg) infected with HIV and enrolled in an intensive 60-day in-patient substance addiction/abuse treatment program were recruited shortly after admission to the treatment facility. Participants were assigned to one of two groups using randomization: supervised resistance exercise 3 times per week using a progressive and non-linear periodized program (Exercise) or no exercise training (Non-Exercise) ...
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