The Regulation of HMG-CoA Reductase by Enzyme-Lipid Interactions
Description:
The temperature-dependent catalytic activity of rat liver 3-hydroxy-3 -methylglutaryl coenzyme A reductase (HMG-CoA reductase) displays the nonlinear Arrhenius behavior characteristic of many membrane-bound enzymes. A two-conformer equilibrium model has been developed to characterize this behavior. In the model, HMG-CoA reductase undergoes a conformational change from a low specific activity to a high specific activity form. This conformation change is apparently driven by a temperature-depende…
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Date:
May 1981
Creator:
Smith, Vana L.
Partner:
UNT Libraries