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A Comparison of Thermogenesis by Selected Substrates on Hypothermic Rat Liver

Description: The thermogenic effects in hypothermia of four substrates--alanine, glycine, ethano, and pyruvate - were studied in seventeen experiments. Albino rats were decapitated, and their livers were removed. The livers were homogenized with phosphate buffer at -5° C. After equilibration in a refrigerated Warburg apparatus at 20° C, the substrates were added and tissue respiration was recorded over three hours. Heat production was calculated from O2 uptake and CO2 production. Results showed that alanine… more
Date: August 1979
Creator: Long, James T.
Partner: UNT Libraries
open access

Effect of Operant Behavior on the Metabolism of 5-Hydroxytryptamine

Description: The role of operant behavior in the metabolism of brain 5-hydroxytryptamine (5-HT) turnover was investigated. Two and one-half hours following the administration of 150 mg/kg of para-chlorophenylalanine (PCPA), a specific inhibitor of tryptophan hydroxylase, levels of 5-HT were compared in sedentary and performing rats. Whole brain levels of serotonin were reduced in both responding and sedentary animals; however, differences between these groups were not statistically significant. The drug ind… more
Date: August 1979
Creator: Shepard, Paul
Partner: UNT Libraries
open access

Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison

Description: A rabbit keratoconjunctivities model was used to evaluate ophthalmic formulations containing 1 percent sodium cephalothin in silicon oil, a 1 percent sodium cephalothin aqueous solution, and a 0.3 percent gentamicin sulfate solution. Rabit eyes were inoculated intracorneally with Pseudomonas aeruginosa, Staphylococcus aureus, or Streptococcus pneumoniae, After topical treatment, none of the antibiotic formulations were effective in the P. aeruginosa model; all three showed good activity agains… more
Date: August 1979
Creator: Carney, Gerald R.
Partner: UNT Libraries
open access

Permeability of the Kidney Capillaries to Narrow-Range Macromolecular Dextran Fractions

Description: Recent investigations into the permeability of the kidney capillaries have produced conflicting reports. This study was an attempt to better describe the permeability of the kidney capillaries by using narrow-range macromolecular dextran fractions in four molecular sizes: MW 61,400, MW 77,000, MW 118,000, and MW 147,000. Permeability was measured by dextran concentration differences in plasma and kidney lymph. Permeability decreased as the dextran molecular weight increased. Molecular weights 6… more
Date: August 1979
Creator: Wooldridge, Clayton Bradley
Partner: UNT Libraries
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