An Approach Towards the Total Synthesis of Clonostachydiol
Description:
The syntheses of the unsymmetrical 14-membered bismacrolides have been reviewed. A total synthesis of clonostachydiol, the latest to join this family, has been attempted using trimethylsilyl acetylene as the builiding block and palladium catalyzed reactions for the formation of key bonds. The alkyne groups were introduced by Stille coupling of trimethylstannylethynyltrimethylsilane with an acid chloride for one fragment and by addition of lithiotrimethylsilyl acetylene to an aldehyde for the ot…
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Date:
August 1995
Creator:
Maiti, Tushar B. (Tushar Baran)
Partner:
UNT Libraries