Association Between Folate, Vitamin B12 and Cognitive Performance in Demented Elderly. Metadata

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Title

  • Main Title Association Between Folate, Vitamin B12 and Cognitive Performance in Demented Elderly.

Creator

  • Author: Serova, Svetlana
    Creator Type: Personal

Contributor

  • Chair: Hall, James
    Contributor Type: Personal
    Contributor Info: Major Professor
  • Committee Member: Bodenhamer-Davis, Eugenia
    Contributor Type: Personal
  • Committee Member: Toledo, Jose
    Contributor Type: Personal
  • Committee Member: Cage, Clifton
    Contributor Type: Personal

Publisher

  • Name: University of North Texas
    Place of Publication: Denton, Texas

Date

  • Creation: 2008-08
  • Digitized: 2009-04-14

Language

  • English

Description

  • Content Description: Dementia is prevalent among elderly people. As the world population ages, it is projected that the number of people affected by dementia may triple in the next 50 years. Over the last two decades, research has focused on identifying potentially modifiable risk factors in development and progression of dementia, such as vitamin B12 and folate. Results concerning the effects of low folate and vitamin B12 on cognitive performance are mixed. The main objective of the present study was to investigate the effects of vitamin deficiency on cognitive functioning in a clinical sample of elderly individuals with cognitive problems using a comprehensive neuropsychological assessment. A retrospective chart-review was performed on the 102 records of patients from the Geriatrics Clinic at the University of North Texas Health Science Center who presented with cognitive deficits. Charts were reviewed to obtain data on vitamin supplementation, vitamin status, history of chronic conditions and other biochemical data. The available database was used to obtain data on neuropsychological assessment. The study demonstrated mild association between vitamin B12 and folate status and cognitive deficits. There appeared to be a higher cut-off level that is above the traditionally used levels for vitamin B12 and folate deficiency concentrations at which cognitive deficits became more pronounced. Clinical applications, limitations and suggestions for future research were discussed.

Subject

  • Keyword: neuropsychological deficits
  • Keyword: Vitamin B12
  • Keyword: folate
  • Keyword: dementia
  • Library of Congress Subject Headings: Cognition in old age.
  • Library of Congress Subject Headings: Folic acid.
  • Library of Congress Subject Headings: Vitamin B12.
  • Library of Congress Subject Headings: Dementia.

Collection

  • Name: UNT Theses and Dissertations
    Code: UNTETD

Institution

  • Name: UNT Libraries
    Code: UNT

Rights

  • Rights Access: public
  • Rights License: copyright
  • Rights Holder: Serova, Svetlana
  • Rights Statement: Copyright is held by the author, unless otherwise noted. All rights reserved.

Resource Type

  • Thesis or Dissertation

Format

  • Text

Identifier

  • OCLC: 361551542
  • Archival Resource Key: ark:/67531/metadc9034

Degree

  • Degree Name: Doctor of Philosophy
  • Degree Level: Doctoral
  • Degree Discipline: Health Psychology and Behavioral Medicine
  • Academic Department: Department of Psychology
  • Degree Grantor: University of North Texas

Note

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