Solubility of Chlordiazepoxide, Diazepam, and Lorazepam in Ethanol + Water Mixtures at 303.2 K

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Article discussing the solubility of chlordiazepoxide, diazepam, and lorazepam in ethanol + water mixtures at 303.2 K.

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4 p.

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Jouyban, Abolghasem; Shokri, Javad; Barzegar-Jalali, Mohammad; Hassanzadeh, Davoud; Acree, William E. (William Eugene); Ghafourian, Taravat et al. April 22, 2009.

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Article discussing the solubility of chlordiazepoxide, diazepam, and lorazepam in ethanol + water mixtures at 303.2 K.

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4 p.

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Abstract: Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam, and lorazepam) in ethanol + water mixtures at 303.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained version of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %, 21.9 % and 19.3 %, respectively, for the fitted model, the trained version for ethanol + water mixtures and generally trained version for various organic solvents + water mixtures.

Reprinted with permission from the Journal of Chemical and Engineering Data. Copyright 2009 American Chemical Society.

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  • Journal of Chemical and Engineering Data, 54(7), American Chemical Society, April 22, 2009, pp. 1-4

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  • Publication Title: Journal of Chemical and Engineering Data
  • Volume: 54
  • Issue: 7
  • Page Start: 2142
  • Page End: 2145
  • Peer Reviewed: Yes

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  • April 22, 2009

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  • Sept. 26, 2014, 9:13 a.m.

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  • Dec. 8, 2023, 10:41 a.m.

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Jouyban, Abolghasem; Shokri, Javad; Barzegar-Jalali, Mohammad; Hassanzadeh, Davoud; Acree, William E. (William Eugene); Ghafourian, Taravat et al. Solubility of Chlordiazepoxide, Diazepam, and Lorazepam in Ethanol + Water Mixtures at 303.2 K, article, April 22, 2009; [Washington, D.C.]. (https://digital.library.unt.edu/ark:/67531/metadc402444/: accessed March 28, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Arts and Sciences.

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