Water-soluble Phosphors for Hypoxia Detection in Chemical and Biological Media Metadata

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Title

  • Main Title Water-soluble Phosphors for Hypoxia Detection in Chemical and Biological Media

Creator

  • Author: Satumtira, Nisa Tara
    Creator Type: Personal

Contributor

  • Chair: Omary, Mohammad A.
    Contributor Type: Personal
    Contributor Info: Major Professor
  • Committee Member: Hunt von Herbing, Ione
    Contributor Type: Personal
  • Committee Member: Verbeck, Guido F.
    Contributor Type: Personal
    Contributor Info: IV
  • Committee Member: Petros, Rob A.
    Contributor Type: Personal
  • Committee Member: Smucker, Brad
    Contributor Type: Personal

Publisher

  • Name: University of North Texas
    Place of Publication: Denton, Texas
    Additional Info: www.unt.edu

Date

  • Creation: 2012-12

Language

  • English

Description

  • Content Description: Water-soluble Pt(II) phosphors exist predominantly for photophysical studies. However, fewer are known to be candidates for cisplatin derivatives. If such a molecule could exist, it would be efficient at not only destroying the cancerous cells which harm the body, but the destruction would also be traceable within the human body as it occurred. Herein, research accomplished in chemistry describes the photophysical properties of a water-soluble phosphor. Spectroscopically, this phosphor is unique in that it possesses a strong green emission at room temperature in aqueous media. Its emission is also sensitive to the gaseous environment. These properties have been expanded to both analytical and biological applications. Studies showing the potential use of the phosphor as a heavy metal remover from aqueous solutions have been accomplished. The removal of toxic heavy metals was indicated by the loss of emission as well as the appearance of a precipitate. The gaseous sensitivity was elicited to be used as a potential cancerous cell biomarker. In vivo studies were accomplished in a wide variety of species, including bacteria (E. coli), worms (C. elegans), small crustaceans (Artemia), and fish (D. rerio and S. ocellatus). The phosphor in question is detectable in all of the above. This fundamental research lays the foundation for further expansion into bioinorganic chemistry, and many other possible applications.

Subject

  • Keyword: Chemistry
  • Keyword: luminescence
  • Keyword: hypoxia

Collection

  • Name: UNT Theses and Dissertations
    Code: UNTETD

Institution

  • Name: UNT Libraries
    Code: UNT

Rights

  • Rights Access: public
  • Rights Holder: Satumtira, Nisa Tara
  • Rights License: copyright
  • Rights Statement: Copyright is held by the author, unless otherwise noted. All rights Reserved.

Resource Type

  • Thesis or Dissertation

Format

  • Text

Identifier

  • Archival Resource Key: ark:/67531/metadc177252

Degree

  • Academic Department: Department of Chemistry
  • Degree Discipline: Inorganic Chemistry
  • Degree Level: Doctoral
  • Degree Name: Doctor of Philosophy
  • Degree Grantor: University of North Texas
  • Degree Publication Type: disse

Note

  • Embargo Note: Restriction lifted in January, 2019.
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