Solubility of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide, 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (Propane-1,2-diol + Water) at a Temperature of 303.2 K

Description:

Article on 7-chloro-2-methylamino-5-phenyl-3H-1, 4-benzodiazepine-4-oxide, 7-chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1, 3-dihydro-1, 4-benzodiazepin-2-one in (propane-1, 2-diol + water) at a temperature of 303.2 K.

Creator(s):
Creation Date: July 31, 2009
Partner(s):
UNT College of Arts and Sciences
Collection(s):
UNT Scholarly Works
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Past 30 days: 6
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Creator (Author):
Jouyban, Abolghasem

Tabriz University of Medical Sciences

Creator (Author):
Shokri, Javad

Tabriz University of Medical Sciences

Creator (Author):
Barzegar-Jalali, Mohammad

Tabriz University of Medical Sciences

Creator (Author):
Hassanzadeh, Davoud

Tabriz University of Medical Sciences

Creator (Author):
Acree, William E. (William Eugene)

University of North Texas

Creator (Author):
Ghafourian, Taravat

Universities of Kent and Greenwich

Creator (Author):
Nokhodchi, Ali

Universities of Kent and Greenwich

Publisher Info:
Publisher Name: American Chemical Society
Place of Publication: [Washington, D.C.]
Date(s):
  • Creation: July 31, 2009
Description:

Article on 7-chloro-2-methylamino-5-phenyl-3H-1, 4-benzodiazepine-4-oxide, 7-chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1, 3-dihydro-1, 4-benzodiazepin-2-one in (propane-1, 2-diol + water) at a temperature of 303.2 K.

Degree:
Department: Chemistry
Note:

Reprinted with permission from the Journal of Chemical and Engineering Data. Copyright 2009 American Chemical Society.

Note:

Abstract: Experimental solubilities of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide (chlordiazepoxide), 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (diazepam), and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one (lorazepam) in (propane-1,2-diol + water) at T = 303.2 K were reported. The solubility of drugs increased with the addition of propane-1,2-diol and reached the maximum values in pure propane-1,2-diol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the back-calculated and predicted values with the corresponding experimental data were 4.2% and 10.7%. The solubilities of the three drugs were also predicted using a trained version of the log−linear model of Yalkowsky, and the OMRD was 21.1%.

Physical Description:

4 p.

Language(s):
Subject(s):
Keyword(s): solubility data | binary solvent mixtures | Jouyban-Acree model
Source: Journal of Chemical and Engineering Data, 2009, Washington D.C.: American Chemical Society, pp. 539-542
Partner:
UNT College of Arts and Sciences
Collection:
UNT Scholarly Works
Identifier:
  • DOI: 10.1021/je900451d |
  • ARK: ark:/67531/metadc172351
Resource Type: Article
Format: Text
Rights:
Access: Public
Citation:
Publication Title: Journal of Chemical and Engineering Data
Volume: 55
Issue: 1
Page Start: 539
Page End: 542
Peer Reviewed: Yes