Towards the timely detection of toxicants

Description:

Article discussing the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, for the specific purpose of studying non-stationary time series.

Creator(s):
Creation Date: April 2004
Partner(s):
UNT College of Arts and Sciences
Collection(s):
UNT Scholarly Works
Usage:
Total Uses: 22
Past 30 days: 8
Yesterday: 0
Creator (Author):
Ignaccolo, Massimiliano

University of North Texas

Creator (Author):
Grigolini, Paolo

University of North Texas; Universit√° di Pisa; Istituto di Biofisica del CNR

Creator (Author):
Gross, Guenter W.

University of North Texas

Publisher Info:
Publisher Name: Elsevier Science Ltd.
Place of Publication: [Amsterdam, Netherlands]
Date(s):
  • Creation: April 2004
Description:

Article discussing the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, for the specific purpose of studying non-stationary time series.

Degree:
Department: Physics
Note:

This is the accepted manuscript version of the article. Reprinted with permission from Elsevier Science Ltd., all rights reserved. The final definitive version is available here: http://dx.doi.org/10.1016/S0960-0779(03)00431-4

Note:

Abstract: We address the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, recently invented for the specific purpose of studying non-stationary time series. The authors study the specific case where the toxicant is tetrodotoxin. This is a very poisonous substance that yields an abrupt drop of the rate of spike production at t approximately 170 minutes when the concentration of toxicant is 4 nanomoles. The CASSANDRA algorithm reveals the influence of toxicants thirty minutes prior to the drop in rate at a concentration of toxicant equal to 2 nanomoles. We argue that the success of this method of analysis rests on the adoption of a new perspective of complexity, interpreted as a condition intermediate between the dynamic and the thermodynamic state.

Physical Description:

6 p.

Language(s):
Subject(s):
Keyword(s): biosensors | CASSANDRA algorithm | tetrodotoxin
Source: Chaos, Solitons and Fractals, 2004, Amsterdam: Elsevier Science Ltd., pp. 87-93
Partner:
UNT College of Arts and Sciences
Collection:
UNT Scholarly Works
Identifier:
  • DOI: 10.1016/S0960-0779(03)00431-4
  • ARK: ark:/67531/metadc139468
Resource Type: Article
Format: Text
Rights:
Access: Public
Citation:
Publication Title: Chaos, Solitons and Fractals
Volume: 20
Issue: 1
Page Start: 87
Page End: 93
Peer Reviewed: Yes