This system will be undergoing maintenance Tuesday, September 30, 2014 from 9:00 AM to 2:00 PM CDT.

Generalized anxiety modulates frontal and limbic activation in major depression

Description:

This article explores how generalized anxiety modulates frontal and limbic activation in major depression. The authors' findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context.

Creator(s):
Creation Date: February 9, 2012
Partner(s):
UNT College of Public Affairs and Community Service
Collection(s):
UNT Scholarly Works
Usage:
Total Uses: 54
Past 30 days: 4
Yesterday: 0
Creator (Author):
Schlund, Michael W.

University of North Texas; Johns Hopkins School of Medicine; Kennedy Krieger Institute

Creator (Author):
Verduzco, Guillermo

Johns Hopkins School of Medicine

Creator (Author):
Cataldo, Michael F.

Johns Hopkins School of Medicine; Kennedy Krieger Institute

Creator (Author):
Hoehn-Saric, Rudolf

Johns Hopkins School of Medicine

Publisher Info:
Publisher Name: BioMed Central Ltd.
Place of Publication: [London, United Kingdom]
Date(s):
  • Creation: February 9, 2012
Description:

This article explores how generalized anxiety modulates frontal and limbic activation in major depression. The authors' findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context.

Degree:
Department: Behavior Analysis
Note:

Abstract: Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited. Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls. Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented. Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.

Physical Description:

5 p.

Language(s):
Subject(s):
Keyword(s): generalized anxiety | depression | frontal | limbic
Source: Behavioral and Brain Functions, 2012, London: BioMed Central Ltd.
Partner:
UNT College of Public Affairs and Community Service
Collection:
UNT Scholarly Works
Identifier:
  • DOI: 10.1186/1744-9081-8-8
  • ARK: ark:/67531/metadc122164
Resource Type: Article
Format: Text
Rights:
Access: Public
Citation:
Publication Title: Behavioral and Brain Functions
Volume: 8
Issue: 8
Peer Reviewed: Yes