Classifying genes to the correct Gene Ontology Slim term in Saccharomyces cerevisiae using neighbouring genes with classification learning

Description:

Article discussing research on classifying genes to the correct gene ontology slim term in Saccharomyces cerevisiae using neighbouring genes with classification learning.

Creator(s):
Creation Date: May 28, 2010
Partner(s):
UNT College of Engineering
Collection(s):
UNT Scholarly Works
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Creator (Author):
Amthauer, Heather A.

Frostburg State University

Creator (Author):
Tsatsoulis, C. (Costas), 1962-

University of North Texas

Publisher Info:
Publisher Name: BioMed Central Ltd.
Place of Publication: [London, United Kingdom]
Date(s):
  • Creation: May 28, 2010
Description:

Article discussing research on classifying genes to the correct gene ontology slim term in Saccharomyces cerevisiae using neighbouring genes with classification learning.

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Abstract: Background: There is increasing evidence that gene location and surrounding genes influence the functionality of genes in the eukaryotic genome. Knowing the Gene Ontology Slim terms associated with a gene gives the authors insight into a gene's functionality by informing the authors how its gene product behaves in a cellular context using three different ontologies: molecular function, biological process, and cellular component. In this study, the authors analyzed if they could classify a gene in Saccharomyces cerevisiae to its correct Gene Ontology Slim term using information about its location in the genome and information from its nearest-neighbouring genes using classification learning. Results: The authors performed experiments to establish that the MultiBoostAB algorithm using the J48 classifier could correctly classify Gene Ontology Slim terms of a gene given information regarding the gene's location and information from its nearest-neighbouring genes for training. Different neighbourhood sizes were examined to determine how many nearest neighbours should be included around each gene to provide better classification rules. The authors' results show that by just incorporating neighbour information from each gene's two-nearest neighbours, the percentage of correctly classified genes to their correct Gene Ontology Slim term for each ontology reaches over 80% with high accuracy (reflected in F-measures over 0.80) of the classification rules produced. Conclusions: The authors confirmed that in classifying genes to their correct Gene Ontology Slim term, the inclusion of neighbour information from those genes is beneficial. Knowing the location of a gene and the Gene Ontology Slim information from neighbouring genes gives us insight into that gene's functionality. This benefit is seen by just including information from a gene's two-nearest neighbouring genes.

Physical Description:

9 p.

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Subject(s):
Keyword(s): Gene Ontology Slim | genes | Saccharomyces cerevisiae
Source: BMC Genomics, 2010, London: BioMed Central Ltd.
Partner:
UNT College of Engineering
Collection:
UNT Scholarly Works
Identifier:
  • DOI: 10.1186/1471-2164-11-340 |
  • ARK: ark:/67531/metadc122144
Resource Type: Article
Format: Text
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Access: Public
Citation:
Publication Title: BMC Genomics
Volume: 11
Issue: 340
Peer Reviewed: Yes