Role of Hypoxia in the Evolution and Development of the Cardiovascular System


Article on the role of hypoxia in the evolution and development of the cardiovascular system.

Creation Date: 2007
UNT College of Arts and Sciences
UNT Scholarly Works
Total Uses: 291
Past 30 days: 3
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Creator (Author):
Fisher, Steven A.

Case Western Reserve School of Medicine

Creator (Author):
Burggren, Warren W.

University of North Texas

Publisher Info:
Publisher Name: Mary Ann Liebert, Inc.
Place of Publication: [New Rochelle, New York]
  • Creation: 2007

Article on the role of hypoxia in the evolution and development of the cardiovascular system.

Department: Biological Sciences

Abstract: How multicellular organisms obtain and use oxygen and other substrates has evolved over hundreds of millions of years in parallel with the evolution of oxygen-delivery systems. A steady supply of oxygen is critical to the existence of organisms that depend on oxygen as a primary source of fuel (i.e., those that live by aerobic metabolism). Not surprisingly, a number of mechanisms have evolved to defend against oxygen deprivation. This review highlights evolutionary and developmental aspects of O(2) delivery to allow understanding of adaptive responses to O(2) deprivation (hypoxia). First, the authors consider how the drive for more efficient oxygen delivery from the heart to the periphery may have shaped the evolution of the cardiovascular system, with particular attention to the routing of oxygenated and deoxygenated blood in the cardiac outlet. Then the authors consider the role of O(2) in the morphogenesis and the cardiovascular system of animals of increasing size and complexity. The authors conclude by suggesting areas for future research regarding the role of oxygen deprivation and oxidative stress in the normal development of the heart and vascular or in the pathogenesis of congenital heart defects.

Physical Description:

15 p.

Keyword(s): oxygen delivery | hypoxia | cardiovascular systems
Source: Antioxidants and Redox Signaling, 2007, New Rochelle: Mary Ann Liebert, Inc., pp. 1339-1353
UNT College of Arts and Sciences
UNT Scholarly Works
  • DOI: 10.1089/ars.2007.1704 |
  • ARK: ark:/67531/metadc115191
Resource Type: Article
Format: Text
Access: Public
Publication Title: Antioxidants and Redox Signaling
Volume: 9
Issue: 9
Page Start: 1339
Page End: 1352
Peer Reviewed: Yes