Acetylcholine-Containing Neuroepithelial Cells in Fish Gills Support the Cholinergic Hypothesis of O2 Chemoreception

Description:

This paper discusses research on how acetylcholine-containing neuroepithelial cells in fish gills support the cholinergic hypothesis of O2 chemoreception.

Creator(s):
Creation Date: April 14, 2011
Partner(s):
UNT Honors College
Collection(s):
UNT Scholarly Works
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Total Uses: 206
Past 30 days: 9
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Creator (Author):
Wanner, Clinton

University of North Texas

Creator (Contributor):
Burleson, Mark L.

University of North Texas; Faculty Mentor; burleson@unt.edu

Publisher Info:
Place of Publication: [Denton, Texas]
Date(s):
  • Creation: April 14, 2011
  • EmbargoUntil: April 14, 2013
Description:

This paper discusses research on how acetylcholine-containing neuroepithelial cells in fish gills support the cholinergic hypothesis of O2 chemoreception.

Degree:
Department: Biological Sciences
Note:

Abstract: The neurochemical link between O2 chemoreceptors and afferent nerves that carry information about O2 levels to cardio-ventilatory centers in the brain has yet to be determined. This study examines the roles of two candidate neurotransmitters thought to be involved in O2 chemoreception, using channel catfish, Ictalurus punctatus. Fish gills are the evolutionary progenitors of arterial arches (aortic and carotid) of mammals where O2 chemoreceptors are located. Neuroepithelial cells (NECs) containing serotonin (5-HT) and acetylcholine (Ach) were confirmed in the first gill arch using immunohistochemistry and laser confocal microscopy. 5-HT-containing NECs were aggregated around the efferent branchial artery, near tips of filaments and lamellae, ACh-containing NECs at the distal tips of filaments. Preliminary co-localization experiments indicate separate 5-HT and Ach-containing cells. This is the first demonstration of ACh-containing NECs and results of this study support pharmacological studies suggesting that ACh is the primary neurochemical involved in O2 chemoreception in vertebrates.

Physical Description:

15 p.

Language(s):
Subject(s):
Keyword(s): O2 chemoreceptors | neurotransmitters | fish gills
Source: The Eagle Feather, 2011, Denton: University of North Texas. Honors College
Contributor(s):
Series Title: University Scholars Day
Partner:
UNT Honors College
Collection:
UNT Scholarly Works
Relation (Is Version Of): Acetylcholine-Containing Neuroepithelial Cells in Fish Gills Support the Cholinergic Hypothesis of O2 Chemoreception, ark:/67531/metadc93292
Identifier:
  • ARK: ark:/67531/metadc86190
Resource Type: Paper
Format: Text
Rights:
Access: Public
Citation:
Publication Title: The Eagle Feather
Issue: 2011
Volume: 8